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- Title
Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning.
- Authors
Moriya, Takahiro; Kouzu, Yasuko; Shibata, Shigenobu; Kadotani, Hiroshi; Fukunaga, Kohji; Miyamoto, Eishichi; Yoshioka, Tohru
- Abstract
AbstractThe general mechanism underlying memory and learning is an area under intense investigation and debate, yet this mechanism still remains elusive. Auditory fear conditioning (when a tone is paired with a foot shock) is a simple associative form of learning for which many mechanistic details are known. Lesions of the lateral/basolateral nuclei of the amygdala result in the selective impairment of fear conditioning, indicating that this is a key region for this type of learning. Fear conditioning induces a lasting synaptic potentiation in the lateral nuclei of the amygdala. In addition, recent results from several laboratories suggest that N-methyl-d-aspartate (NMDA) receptor activation in the amygdala is required for the acquisition and expression of cue-conditioned fear responses using several kinds of antagonists. Little is known, however, about the signal transduction pathway and molecular substrate underlying fear conditioning. Here we use NMDA receptor-deficient mice to demonstrate that calmodulin-dependent kinase II, CaMKIIβ, and CaMKIIα activation involves the NR2A subunit in the lateral/basolateral amygdala during memory retrieval following auditory fear conditioning. These results suggest that auditory fear conditioning involves a close linkage between NMDA2A receptors and the CaMKII cascade.
- Subjects
CALMODULIN; AUDITORY cortex; METHYL aspartate; DEFICIENCY diseases; AUDITORY evoked response; PHYSIOLOGY
- Publication
European Journal of Neuroscience, 2000, Vol 12, Issue 9, p3307
- ISSN
0953-816X
- Publication type
Article
- DOI
10.1046/j.1460-9568.2000.00203.x