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- Title
IL-4 within the bone marrow: a key driver of lung tumorigenesis.
- Authors
Tanaka, Yoshimasa
- Abstract
A recent study published in the Journal of Leukocyte Biology by LaMarche et al. reveals that interleukin (IL)-4 within the bone marrow plays a crucial role in promoting lung tumorigenesis. The research demonstrates that blocking IL-4 receptor α chain (IL-4Rα) in combination with PD-1 immune checkpoint inhibitors reduces circulating monocytes and increases tumor-infiltrating CD8+ T cells in patients with non-small cell lung cancer (NSCLC). The study also identifies basophils in the bone marrow as the source of IL-4 and highlights the potential for IL-4 blockade as a novel cancer immunotherapy targeting the immunosuppressive tumor microenvironment. The findings suggest a promising strategy for developing mechanism-based therapies for NSCLC.
- Subjects
BONE marrow; T-cell exhaustion; LUNGS; BONE marrow cells; LUNG development
- Publication
Journal of Leukocyte Biology, 2024, Vol 115, Issue 5, p791
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1093/jleuko/qiae033