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- Title
Vascular and metabolic properties of manidipine.
- Authors
Ríos, N. Buset; Esparragón, F. Rodríguez; Rodríguez, C. Fernández-Andrade; Pérez, J. C. Rodríguez
- Abstract
The combination of renin-angiotensin system blockers with calcium channel blockers appears to be one of the most effective options for treating hypertension and diabetes. Nevertheless, not all calcium blockers behave in the same manner. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria. In addition, T-type channels are related to proliferation, inflammation, fibrosis, vasoconstriction and activation of the renin- angiotensin system. The inhibition of these factors could explain the non-haemodynamic effects of manidipine as compared to other blockers.
- Subjects
DRUG metabolism; CALCIUM antagonists; HYPERTENSION; THERAPEUTICS; TREATMENT of diabetes; CARDIOVASCULAR diseases; ANTIHYPERTENSIVE agents; RENIN-angiotensin system
- Publication
Nefrologia, 2011, Vol 31, Issue 3, p268
- ISSN
0211-6995
- Publication type
Article
- DOI
10.3265/Nefrologia.pre2010.Nov.10643