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- Title
Brazilian Curcuma longa L. attenuates comorbidities by modulating adipose tissue dysfunction in obese rats.
- Authors
Lo, Angelo Thompson Colombo; Francisqueti, Fabiane Valentini; Hasimoto, Fabiana Kurokawa; Ferraz, Ana Paula Costa Rodrigues; Minatel, Igor Otávio; Garcia, Jéssica Leite; dos Santos, Klinsmann Carolo; Alves, Pedro Henrique Rizzi; Lima, Giuseppina Pace Pereira; Moreto, Fernando; Ferron, Artur Junio Togneri; Corrêa, Camila Renata
- Abstract
Background: Adipose tissue dysfunction is a condition characterized by inflammation and oxidative stress able to lead metabolic disorders. Curcuma longa L. (Cl) is a rhizome commonly used in Indian culinary which presents anti-inflammatory and antioxidant compounds. The aim of this study was to evaluate the effect of in natura Curcuma longa L. on adipose tissue dysfunction and comorbidities in obese rats. Methods: Male Wistar rats (8 weeks old, n = 16) received standard chow + fructose in drinking water (30%) ad libitum for 16 weeks. After this period, animals were randomly divided to receive placebo treatment (fructose, n = 8) or Curcuma longa L. treatment (fructose + Cl, n = 8) for more 8 weeks, totalizing 24 weeks of experiment. Curcuma longa L. was mixed in water and gave to the animals by gavage in a dose of 80 mg/kg of body weight. Body composition, systolic blood pressure, metabolic, hormonal, inflammatory, and oxidative stress analysis were performed in plasma and adipose tissue. Results: Curcuma longa L. reduced adiposity index and adipocyte hypertrophy, improved insulin resistance and systolic blood pressure, and reduced inflammation and oxidative stress in adipose tissue. Conclusion: Curcuma longa L. in natura is able to modulate adipose tissue dysfunction, avoiding the development of comorbidities. It can be considered a phytochemical treatment strategy against obesity-related chronic diseases.
- Subjects
TURMERIC; COMORBIDITY; ADIPOSE tissue diseases; OBESITY in animals; LABORATORY rats
- Publication
Nutrire, 2018, Vol 43, Issue 1, pN.PAG
- ISSN
2316-7874
- Publication type
Article
- DOI
10.1186/s41110-018-0085-y