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- Title
The electroneutral Na(+)-(K+)-Cl- cotransport family.
- Authors
Hebert, Steven C.; Gamba, Gerardo; Kaplan, Mark; Hebert, S C; Gamba, G; Kaplan, M
- Abstract
Recently the molecular identification of the major electroneutral sodium-potassium-chloride entry mechanisms present on apical membranes of distal nephron segments of the mammalian kidney, on basolateral membranes of many non-renal epithelial cells and on certain non-epithelial tissues has been achieved. These transporters represent a major pathway for cellular uptake of chloride critical for chloride absorptive and secretory processes and for cell volume regulation following cell shrinkage. In the mammalian kidney, these sodium-coupled chloride cotransporters represent the major target sites for clinically useful diuretics including the "loop" diuretics [furosemide (Lasix) and bumetanide (Bumex)] and thiazides (such as, chlorothiazide, hydrochlorothiazide and metolazone). Although these Na-(K)-Cl cotransporters exhibit functional and pharmacological differences, they clearly evolved from a common ancestral gene and thus form a new gene family. This information is already advancing our understanding of the evolution, structure and function of these transporters both in renal handling of sodium and in hypertension.
- Subjects
KIDNEY tubules; ACTIVE biological transport; ION channels; MAMMALS; DIURETICS; HYPERTENSION
- Publication
Kidney International, 1996, Vol 49, Issue 6, p1638
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.1996.238