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- Title
Dissociation of glomerular filtration and renal blood flow in HgCI[SUB2]-induced acute renal failure.
- Authors
Vanholder, Raymond C.; Praet, Marleen M.; Pattyn, Piet A.; Leusen, Isidoor R.; Lameire, Norbert H.
- Abstract
This study evaluates the role of early renal vasoconstriction in the pathogenesis of mercuric chloride (HgCl2)-induced acute renal failure (ARF) in the dog. Within 3 hr after mercury, glomerular filtration rate (GFR), from 45 ± 4 to 25 ± 2 ml/min, and renal blood flow (RBF), from 268 ± 22 to 161 ± 19 ml/min, decreased simultaneously. A rise in diuresis and urinary solute excretion occurred. Morphological and functional studies excluded a major role for tubular leakage or obstruction. An attempt was made to prevent the early renal vasoconstriction, by the administration of Haemaccel® a plasma volume expander, alone or in combination with phentolamine. In both settings the fall in RBF after mercury was prevented. Haemaccel® volume expansion alone provoked a significant rise in GFR before HgCl2, but the GFR fell by 29% 3 hr after HgCl2. The Haemaccel® phentolamine combination had no influence on pre-mercury GFR values. In this group, a decrease of GFR by 44% was noted 3 hr after mercury. In conclusion, changes in GFR and renal hemodynamics can be dissociated in the early phase of nephrotoxic ARF. The fall in GFR can be attributed either to a decrease in glomerular ultrafiltration capacity and/or changes in glomerular afferent and efferent resistances, leading to a decrease in glomerular hydrostatic pressure.
- Subjects
RENAL circulation; BLOOD circulation; BLOOD flow; KIDNEY glomerulus; ACUTE kidney failure; MERCURIC chloride
- Publication
Kidney International, 1982, Vol 22, Issue 2, p162
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1982.148