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- Title
Efficacy of AST-120 in Dogs with Chronic Idiopathic Enteropathies.
- Authors
Volkmann, M.; Wirtherle, N.C.; Beddies, G.F.; Kohn, B.
- Abstract
Background Chronic idiopathic enteropathies ( CIE) in dogs are complex diseases of unknown origin. AST-120 is a spherical carbon adsorbent preparation with a high adsorption ability for low molecular substances. Objectives Evaluation of the clinical efficacy of AST-120 in dogs with CIE. Animals Ten client-owned dogs with mild (n = 7) to moderate (n = 3) CIE. Methods Explorative, prospective, randomized, placebo-controlled, double-blinded pilot study. Dogs with chronic diarrhea and no or insufficient response to an elimination diet were included. The dogs received either AST-120 (n = 5) or placebo (n = 5) for a duration of 21 days. The canine inflammatory bowel disease activity index ( CIBDAI) was used to assess disease severity at baseline and clinical outcome after 3 weeks of treatment. Furthermore, changes in body weight and the parameters stool consistency and frequency were compared within and between groups. Results The mean CIBDAI score decreased from 5.6 ( SD 1.5) to 2.0 ( SD 1.2) in the AST-120 group ( P = .125) and from 4.8 ( SD .8) to 3.6 ( SD 2.3) in the placebo group ( P = .688). Compared with baseline, posttreatment CIBDAI scores decreased more than 60% in 4/5 dogs treated with AST-120 and in 1/5 dogs treated with placebo ( P = .206). Changes in CIBDAI scores, body weights, stool consistency, and frequency within and between groups did not achieve statistical significance after 3 weeks of treatment. No adverse effects of AST-120 were noted. Conclusions and Clinical Importance This study investigated potential efficacy of AST-120 as an alternative therapy in dogs with mild-to-moderate CIE.
- Subjects
DOG diseases; DRUG efficacy; INTESTINAL diseases; CHRONIC diseases; SORBENTS; RANDOMIZED controlled trials
- Publication
Journal of Veterinary Internal Medicine, 2013, Vol 27, Issue 6, p1637
- ISSN
0891-6640
- Publication type
Article
- DOI
10.1111/jvim.12212