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- Title
When is a Kupffer cell not a Kupffer cell? Novel insight into macrophage fate and function in hepatic fibrosis.
- Authors
Arteel, Gavin E
- Abstract
This article explores the identity and function of Kupffer cells in the liver, which are phagocytic cells involved in immune response and clearance of toxins. The authors discuss how severe liver fibrosis affects the phenotype and function of Kupffer cells, leading to impaired phagocytic activity. They also describe the formation of Kupffer cell-like syncytia in intrahepatic shunts as an adaptive response to maintain immune clearance. The study suggests that these findings may have implications for understanding liver diseases and potential therapeutic interventions. However, further research is needed to fully understand the temporal response and specific functions of these syncytia in different types of liver fibrosis.
- Subjects
KUPFFER cells; HEPATIC fibrosis; CHOLANGITIS; MACROPHAGES; LIVER cells; PHAGOCYTOSIS; CELL anatomy
- Publication
Journal of Leukocyte Biology, 2024, Vol 115, Issue 3, p415
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1093/jleuko/qiae005