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- Title
Peripheral Nerve Injury Induces Down-Regulation of Foxo3a and p27<sup>kip1</sup> in Rat Dorsal Root Ganglia.
- Authors
Ying Chen; Shuxian Shi; Jing Qin; Feng Xiao; Dan Zhou; Mudan Lu; Qiuyan Lu
- Abstract
Abstract FOXO3a, as a forkhead transcription factor, can control cell cycle through transcriptionally down-regulating p27kip1 level, which is a key regulator of the mammalian cell cycle and a good candidate to regulate multiple aspects of neurogenesis. To elucidate their expression and function in nervous system lesion and repair, we performed an acute sciatic nerve crush model and studied differential expressions of Foxo3a and p27kip1 in lumbar dorsal root ganglia. Temporally, Foxo3a protein level was reduced 1 day after injury, and following Foxo3a down-regulation, p27kip1 mRNA and protein levels were also decreased after injury. Spatially, decreased levels of Foxo3a and p27kip1 were predominant in neurons and glial cells, which were regenerating axons and largely proliferated after injury, respectively. Together with previous reports, we hypothesized decreased levels of Foxo3a and p27kip1 in lumbar dorsal root ganglia were implicated in axonal regeneration and the proliferation of glial cells after sciatic nerve injury.
- Subjects
PERIPHERAL nerve injuries; GENETIC transcription regulation; TRANSCRIPTION factors; CELL cycle regulation; SPINAL ganglia; NEUROGLIA; CELL proliferation
- Publication
Neurochemical Research, 2009, Vol 34, Issue 5, p891
- ISSN
0364-3190
- Publication type
Article