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- Title
COLORECTAL CANCER, NOVEL BIOMARKERS AND IMMUNOHISTOCHEMISTRY -- AN OVERVIEW.
- Authors
Ulamec, Monika; Krušlin, Božo
- Abstract
Colorectal cancer (CRC) is the most common cancer in Europe and the leading cause of death. A combination of therapy with targeted agents and the knowledge of many biomarkers is significantly increasing to better guide the selection of treatment. Biomarkers that are currently used as predictive and prognostic, as well as factors for therapy selection, are described in this overview. It refers to microsatellite instability (MSI), RAS-family of oncogenes, BRAF, TP53, Ki-67, Oncotype DX_, phosphatidylinosi-tol 3-kinase (PI3K)/AKT, 18q LOH, and CpG island methylator phenotype. Only a few biomarkers are currently used and in routine reported by pathologists. Future studies need to consider the combination of markers, standardising protocols and, if possible, simple and standardised assays for the detection of molecular markers.
- Subjects
COLON cancer; BIOMARKERS; MICROSATELLITE repeats; BRAF genes; IMMUNOHISTOCHEMISTRY; CAUSES of death
- Publication
Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanosti, 2014, Vol 520, Issue 40, p41
- ISSN
1330-5301
- Publication type
Article