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- Title
Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis.
- Authors
Leipner, Carola; Grü, Katja; Müller, Andreas; Buchdunger, Elisabeth; Borsi, Laura; Kosmehl, Hartwig; Berndt, Alexander; Janik, Tobias; Uecker, Andrea; Kiehntopf, Michael; Böhmer, Frank-D.
- Abstract
Aims: Coxsackievirus B3 (CVB3)-induced chronic myocarditis in mice is accompanied by severe fibrosis and by sustained elevation of platelet-derived growth factor (PDGF)-A, -B, and -C levels in the cardiac tissue. To test if PDGF stimulation of resident fibroblasts causally contributes to fibrosis, we employed inhibition of PDGF receptor signalling with the orally available kinase inhibitor Imatinib.
- Subjects
IMATINIB; FIBROSIS; COXSACKIEVIRUSES; MYOCARDITIS; ANTINEOPLASTIC agents
- Publication
Cardiovascular Research, 2008, Vol 79, Issue 1, p118
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvn063