We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transendothelial exchange of low-density lipoprotein is unaffected by the presence of severe atherosclerosis
- Authors
Kornerup, Karen; Nordestgaard, Børge Grønne; Jensen, Trine Krogsgaard; Feldt-Rasmussen, Bo; Eiberg, Jonas Peter; Jensen, Kurt Svarre; Jensen, Jan Skov
- Abstract
We tested the hypothesis that transendothelial exchange of low-density lipoprotein (LDL) is influenced by the presence of severe atherosclerosis; we previously found this exchange elevated in diabetes patients.By an in vivo isotope method, we compared transendothelial LDL exchange in 24 patients with angiographically verified coronary atherosclerosis, 11 patients with angiographically verified peripheral atherosclerosis, 60 patients with diabetes, and in 42 controls. Autologous 131-iodinated LDL (131I-LDL) and 125-iodinated albumin (125I-albumin) were injected intravenously (i.v.), and the 1-h fractional escape rates (FERLDL and FERalb) were taken as indices of transendothelial exchange.Patients with coronary or peripheral atherosclerosis had FERLDL similar to that of controls [4.3 (3.5–5.1) and 3.2 (2.3–4.1) versus 4.2 (3.7–4.7)%/h; P>0.05], even after adjustment for LDL distribution volume (DVLDL). In contrast, diabetes patients had significantly higher FERLDL than controls [5.2 (4.6–5.7) versus 4.2 (3.7–4.7)%/h; P<0.05]. This difference was even more pronounced after correction for the distribution volume of LDL. Compared with controls, FERalb was not elevated in patients with coronary atherosclerosis, possibly elevated in patients with peripheral atherosclerosis, but was elevated in diabetes patients. There was a tight positive correlation between FERLDL and FERalb in all groups of patients and controls.Transendothelial exchange of low-density lipoprotein is not elevated in patients having severe atherosclerosis. This suggests that the observed vascular leakiness in diabetes precedes and possibly contributes to accelerated atherosclerosis in diabetes.
- Subjects
LIPID metabolism; LIPOPROTEINS; ATHEROSCLEROSIS; DIABETES
- Publication
Cardiovascular Research, 2004, Vol 64, Issue 2, p337
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1016/j.cardiores.2004.06.025