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- Title
Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome.
- Authors
Saltevo, Juha; Vanhala, Mauno; Kautiainen, Hannu; Kumpusalo, Esko; Laakso, Markku
- Abstract
This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects withoutMetS compared to subjects withMetS. IfMetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.
- Subjects
FINLAND; C-reactive protein; INTERLEUKIN-1; METABOLIC disorders; POPULATION genetics
- Publication
Mediators of Inflammation, 2007, Vol 2007, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2007/93573