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- Title
Electroporation-medicated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis.
- Authors
Nakamura, Hiroyuki; Isaka, Yoshita; Tsujie, Michiko; Akagi, Yoshita; Sudo, Tetsuo; Ohno, Noriko; Imai, Enyu; Hori, Masatsugu
- Abstract
Presents a study on the feasibility of gene therapy by the manipulation of platelet-derived growth factor (PDGF) action, using electroporation-mediated PDGF receptor fused with IgG-Fc gene transfer, in treating glomerulonephritis. Role of glomerular mesangial cells and mesangial extracellular matrix in the development of glomerulosclerosis and renal failure; Methodology; Results and discussion.
- Subjects
GENE therapy; TREATMENT of glomerulonephritis; PLATELET-derived growth factor; ELECTROPORATION therapy
- Publication
Kidney International, 2001, Vol 59, Issue 6, p2134
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.2001.00728.x