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- Title
Visible Spectrophotometric Methods for the Estimation of Metoclopramide Hydrochloride in Tablets.
- Authors
Patel, S. A.; Patel, C. N.; Patel, M. M.
- Abstract
Two simple, sensitive, accurate, and rapid visible spectrophotometric methods have been developed for the estimation of metoclopramide hydrochloride in tablets. Method A is based on the reaction of drug with 4-dimethyl aminobenzaldehyde (Ehrlich reagent) to yield a yellow colour Schiff 's base, which shows maximum absorbance at 438 nm against reagent blank, while method B is based on diazotisation of primary amine group of metoclopramide hydrochloride with sodium nitrite and hydrochloric acid followed by coupling with β-napthol (in alkaline medium) to form a red colour dye, which shows maximum absorbance at 553 nm against reagent blank. Beer's law was obeyed in the concentration range of 10-100 µg/ml in method A and 1-10 µg/ml in method B. Results of the analysis were validated statistically and by recovery studies.
- Subjects
DRUGS; PHARMACOLOGY; HYDROCHLORIC acid; AMINES; ORGANIC compounds
- Publication
Indian Journal of Pharmaceutical Sciences, 2006, Vol 68, Issue 3, p397
- ISSN
0250-474X
- Publication type
Article
- DOI
10.4103/0250-474X.26663