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- Title
Higher menopausal age but no differences in parity in women with polycystic ovary syndrome compared with controls.
- Authors
Forslund, Maria; Landin‐Wilhelmsen, Kerstin; Schmidt, Johanna; Brännström, Mats; Trimpou, Penelope; Dahlgren, Eva; Landin-Wilhelmsen, Kerstin
- Abstract
<bold>Introduction: </bold>To address the question of whether women with polycystic ovary syndrome (PCOS) reach menopause later than age-matched controls, we conducted a follow-up cohort study of women with well-characterized PCOS that was diagnosed 24 years ago. The hypothesis was that women with PCOS would reach menopause later than non-PCOS women. Parity during these 24 years was also studied.<bold>Material and Methods: </bold>Twenty-seven women diagnosed with PCOS in 1992 (mean age 29.5 years) were re-examined in 2016 (mean age 52.4 years). Randomly selected women, n = 94 (mean age 52.4 years), from the same geographic area included in the World Health Organization MONICA study, Gothenburg, Sweden, served as controls.<bold>Results: </bold>The mean menopausal age in women with PCOS was higher than in controls (53.3 ± 2.2 years vs 49.3 ± 3.5 years, P < 0.01). Serum-follicle stimulating hormone levels were lower in the PCOS women than in controls (31.0 ± 28.1 IU/L vs 52.3 ± 37.7 IU/L, P = 0.01). There was no difference in parity between women with PCOS (1.9 ± 1.3 children, range 0-4) and controls (1.7 ± 1.0, range 0-4 children).<bold>Conclusions: </bold>Women with PCOS reached menopause 4 years later and had lower serum-follicle stimulating hormone compared with age-matched controls. Neither parity nor nulliparity differed between women with PCOS and controls.
- Subjects
SWEDEN; POLYCYSTIC ovary syndrome; OVARIAN reserve; COHORT analysis; WORLD health
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2019, Vol 98, Issue 3, p320
- ISSN
0001-6349
- Publication type
journal article
- DOI
10.1111/aogs.13489