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- Title
Pregnancy outcomes after liver transplantation in Finland.
- Authors
Mattila, Mirjami; Kemppainen, Helena; Isoniemi, Helena; Polo-Kantola, Päivi
- Abstract
<bold>Introduction: </bold>Pregnancy after liver transplantation is possible but associated with increased risk of obstetrical complications. We report here for the first time the pregnancy outcomes after liver transplantation in Finland.<bold>Material and Methods: </bold>All of the 25 pregnancies ending in deliveries after liver transplantation in Finland in 1998-2015 were analyzed. The data were collected from the mothers' medical records. The main outcome measures included pregnancy complications and the mode of delivery. Neonatal outcome measures were birthweight, 5-min Apgar score and umbilical artery pH.<bold>Results: </bold>Twenty-six infants were born. Of all deliveries, 76% occurred at the ≥37 weeks of gestation and the average birthweight was 3040 g. Apgar scores were ≥7 in 25/26 (96%) of the infants and cases of birth asphyxia (umbilical artery pH ≤ 7.05) were not detected. Cesarean section rate was 32%. Preeclampsia occurred in 12% of the women and the preterm delivery rate was 24%. Co-morbidities (hypertension, intrahepatic cholestasis of pregnancy, Hodgkin's disease, colitis ulcerosa, epileptic attacks, cholangitis, splenic artery rupture, renal insufficiency and graft rejection) complicated 52% of pregnancies.<bold>Conclusion: </bold>Pregnancies after liver transplantation in Finland result in good perinatal outcome with healthy, mostly full-term, normally grown offspring; however, serious maternal complications related to underlying liver pathology, transplant surgery and immunosuppressive medication occur frequently.
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2017, Vol 71, pN.PAG
- ISSN
0001-6349
- Publication type
journal article
- DOI
10.1111/aogs.13175