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- Title
HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.
- Authors
Janes, Holly; Herbeck, Joshua T; Tovanabutra, Sodsai; Thomas, Rasmi; Frahm, Nicole; Duerr, Ann; Hural, John; Corey, Lawrence; Self, Steve G; Buchbinder, Susan P; McElrath, M Juliana; O'Connell, Robert J; Paris, Robert M; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Pitisuttihum, Punnee; Kaewkungwal, Jaranit; Robb, Merlin L; Michael, Nelson L; Mullins, James I
- Abstract
Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found-in two different cohorts-that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
- Subjects
HIV infections; VIRAL load; CD4 lymphocyte count; FOUNDER effect; HLA histocompatibility antigens; GENE amplification
- Publication
Nature Medicine, 2015, Vol 21, Issue 10, p1139
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm.3932