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- Title
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.
- Authors
Ichikawa, Kimihisa; Weimin Liu; Limin Zhao; Zheng Wang; Di Liu; Ohtsuka, Toshiaki; Huangge Zhang; Mountz, John D.; Koopman, William J.; Kimberly, Robert P.; Tong Zhou
- Abstract
Studies the tumoricidal activity of the anti-human DR5 monoclonal antibody TRA-8. Apoptosis of tumor necrosis factor-related apoptosis-inducing ligand-sensitive tumor cells; Characteristics of TRA-8; DR5 as a death receptor on most tumor cells; DR5 protein expression in normal and cancer tissues.
- Subjects
MONOCLONAL antibodies; TUMOR necrosis factors; APOPTOSIS
- Publication
Nature Medicine, 2001, Vol 7, Issue 8, p954
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/91000