We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anti-Psoriatic Therapy Recovers High-Density Lipoprotein Composition and Function.
- Authors
Holzer, Michael; Wolf, Peter; Inzinger, Martin; Trieb, Markus; Curcic, Sanja; Pasterk, Lisa; Weger, Wolfgang; Heinemann, Akos; Marsche, Gunther
- Abstract
Psoriasis is a chronic inflammatory disorder associated with increased cardiovascular mortality. Psoriasis affects high-density lipoprotein (HDL) composition, generating dysfunctional HDL particles. However, data regarding the impact of anti-psoriatic therapy on HDL composition and function are not available. HDL was isolated from 15 psoriatic patients at baseline and after effective topical and/or systemic anti-psoriatic therapy and from 15 age- and sex-matched healthy controls. HDL from psoriatic patients showed a significantly impaired capability to mobilize cholesterol from macrophages (6.4 vs. 8.0% [3H]cholesterol efflux, P<0.001), low paraoxonase (217 vs. 350 μM−1 minute−1 mg−1 protein, P=0.011) and increased Lp-PLA2 activities (19.9 vs. 12.1 nM−1 minute−1 mg−1 protein, P=0.028). Of particular interest, the anti-psoriatic therapy significantly improved serum lecithin-cholesterol acyltransferase activity and decreased total serum lipolytic activity but did not affect serum levels of HDL-cholesterol. Most importantly, these changes were associated with a significantly improved HDL-cholesterol efflux capability. Our results provide evidence that effective anti-psoriatic therapy recovers HDL composition and function, independent of serum HDL-cholesterol levels, and support to the emerging concept that HDL function may be a better marker of cardiovascular risk than HDL-cholesterol levels.
- Subjects
HIGH density lipoproteins; INFLAMMATION; PSORIASIS treatment; CARDIOVASCULAR disease related mortality; CHOLESTEROL; MACROPHAGES; PARAOXONASE
- Publication
Journal of Investigative Dermatology, 2014, Vol 134, Issue 3, p635
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2013.359