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- Title
Higher Serum Levels of Interleukin 10 Occur at Onset of Acute Otitis Media Caused by Streptococcus Pneumoniae Compared to Haemophilus Influenzae and Moraxella Catarrhalis.
- Authors
Liu, Keyi; Kaur, Ravinder; Almudevar, Anthony; Pichichero, Michael E.
- Abstract
Objectives/Hypothesis Acute otitis media ( AOM) involves an inflammatory response to microbes in the middle ear that facilitates clearance of otopathogens. Clinically , Streptococcus pneumoniae (Spn) infections of the respiratory tract are characterized by greater inflammatory responses than nontypeable Haemophilus influenzae ( NTHi) and Moraxella catarrhalis (Mcat). Interleukin 10 ( IL-10) plays an important role in down-regulating the inflammatory response. We compared serum IL-10 levels in children before onset, at onset, and after recovery from AOM caused by Spn, NTHi, and Mcat. We sought to determine if IL-10 could serve as a biomarker to distinguish AOM caused by Spn versus NTHi and Mcat. Study Design Prospective, longitudinal study in a primary care pediatric practice in Rochester, NY. Methods Participants were 54 children, 6 to 30 months of age. Outcomes measured were serum IL-10 levels when healthy, at onset of AOM, and after recovery from AOM. Results Serum IL-10 was elevated when children developed AOM ( P=0.013) due to infections caused by Spn ( P=0.011) but not AOM caused by NTHi or Mcat. Middle ear fluid levels of IL-10 mirrored those seen in serum but were 10-fold higher ( P=0.02). Other effector cytokines in serum: IL-4, IFN-γ, and TNF-alpha, did not show the same increases as IL-10 at onset of AOM. Conclusion Our study indicates that AOM caused by Spn elicits a significantly higher IL-10 response compared to NTHi and Mcat and may prove to be a biomarker of AOM infections by Spn. Level of Evidence 4.
- Subjects
ACUTE otitis media; INTERLEUKINS; STREPTOCOCCUS pneumoniae; HAEMOPHILUS influenzae; MORAXELLA catarrhalis; TREATMENT of middle ear abnormalities; DIAGNOSIS
- Publication
Laryngoscope, 2013, Vol 123, Issue 6, p1500
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.23973