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- Title
Reconstruction of Parotidectomy Defects in the Rat Model: A Comparison of Alloderm versus DermaMatrix.
- Authors
Athavale, Sanjay M.; Rangarajan, Sanjeet V.; Dharamsi, Latif; Wentz, Sabrina; Phillips, Sharon E.; Yarbrough, Wendell G.
- Abstract
Objectives: We looked to analyze tissue incorporation, immune response, and neovascularization of Alloderm™ and DermaMatrix™ in a rat model to determine which implant would be better suited for use in the post-parotidectomy bed. To our knowledge, this is the first study to examine histological differences between both implants in a postparotidectomy animal model. Study Design: A prospective rat study comparing Alloderm™ and DermaMatrix™ in the postparotidectomy bed and dorsum. Methods: Eight male Sprague- Dawley rats were used. In each rat, three folded Alloderm™ implants were placed in the post-parotidectomy bed and three were placed in the dorsum as controls. The same was done for DermaMatrix™. Two animals were sacrificed at 4, 8, and 12 days. A blinded pathologist assessed the degree of fibroblast proliferation, microvessels, and inflammatory cells present in each section of implant. Results: Significant differences between type and location of implants were more prevalent at later time points. In the parotid gland, Alloderm™ showed higher degrees of fibroblast proliferation at eight days (p = 0.0106), with no significant differences with DermaMatrix™ in the number of inflammatory cells or degree of neovascularization. When compared with the dorsum, DermaMatrix™ implants in the parotid gland had higher numbers of inflammatory cells at eight and twelve days, with 14.17 (p = 0.0490) and 33.33 (p = 0.0046) cells per section respectively. Conclusions: Our study showed that there are mild postoperative histologic differences between Alloderm™ and DermaMatrix™ in the postparotidectomy bed. The unique properties of each implant could potentially be a source of differing complication profiles in humans.
- Subjects
BLOOD-vessel development; IMMUNE response; PAROTID glands; NEOVASCULARIZATION; LABORATORY rats
- Publication
Laryngoscope, 2011, Vol 121, Issue S5, pS269
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.22220