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- Title
High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD)
- Authors
Cascinu, S.; Scartozzi, M.; Labianca, R.; Catalano, V.; Silva, R. R.; Barni, S.; Zaniboni, A.; Angelo, A. D.; Salvagni, S.; Martignoni, G.; Berardi, R.; Graziano, F.; Beretta, G. D.; Franciosi, V.
- Abstract
The aim of the present study was to evaluate the role of a weekly preoperative chemotherapy in locally advanced, unresectable gastric cancer. In all, 82 patients with an Eastern Oncology Cooperative Group PS ?2 and normal cardiac function were enrolled onto the study. Surgical unresectability was confirmed in 52 patients (63%) at laparotomy, and in 30 (27%) cases by CT scan of the abdomen and endoscopic ultrasonography. Chemotherapy treatment was: cisplatin 40?mg?m-2; 5-fluorouracil 500?mg?m-2; epidoxorubicin 35?mg?m-2; 6S-leucovorin 250?mg?m-2 and glutathione 1.5?g?m-2 (PELF). One cycle consisted of 8 weekly treatments. Response to chemotherapy was observed in 40 of 82 patients (49%): six (7%) complete and 34 (41%) partial responses, and in four (5%) cases a complete pathological response was confirmed. Of the 40 responding patients, 37 (45%) had potentially curative surgery. Grade 3/4 leucopenia and thrombocytopenia occurred in three and two patients. At a median follow-up of 48 months, 25 of the 37 resected patients (68%) were alive and 24 (65%) were disease free. The median and 4-year survival for the whole group was 17 months and 31%, respectively. The median survival was 12 months for inoperable patients and it was not reached in resected patients.British Journal of Cancer (2004) 90, 1521-1525. doi:10.1038/sj.bjc.6601752www.bjcancer.com Published online 30 March 2004
- Subjects
GASTROINTESTINAL cancer; PREOPERATIVE care; DRUG therapy; ADJUVANT treatment of cancer; SURGICAL excision
- Publication
British Journal of Cancer, 2004, Vol 90, Issue 8, p1521
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/sj.bjc.6601752