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- Title
Targeting Non-Replicating Mycobacterium tuberculosis and Latent Infection: Alternatives and Perspectives (Mini-Review).
- Authors
Egorova, Anna; Salina, Elena G.; Makarov, Vadim
- Abstract
Latent tuberculosis infection (LTBI) represents a major challenge to curing TB disease. Current guidelines for LTBI management include only three older drugs and their combinations—isoniazid and rifamycins (rifampicin and rifapentine). These available control strategies have little impact on latent TB elimination, and new specific therapeutics are urgently needed. In the present mini-review, we highlight some of the alternatives that may potentially be included in LTBI treatment recommendations and a list of early-stage prospective small molecules that act on drug targets specific for Mycobacterium tuberculosis latency.
- Subjects
MYCOBACTERIUM tuberculosis; SMALL molecules; DRUG target; TUBERCULOSIS; RIFAMYCINS; PYRAZINAMIDE
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 24, p13317
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222413317