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- Title
Fructose during suckling and into weaning promotes increased body weight in young adult rats prior to affecting glucose or fatty acid metabolism.
- Authors
Bomhof, Marc Richard; Wright, David C.; Hoedl, Abha; Turchinsky, Joan; Coumans, Will; Luiken, Joost J. J. P.; Bell, Rhonda C.
- Abstract
This study examined the effect of initiating fructose (FR) feeding during suckling and maintaining FR post-weaning on body weight, glucose and fatty acid metabolism. Rat pups (12 days old) were randomly assigned to 1 of 3 diets; suckle controls (SC), FR-containing formula, or rat milk substitute (RMS) formula. FR or RMS formulae were given by artificial rearing until 20 days old. From weaning until 6 weeks of age, half of SC were fed AIN 93G (SC-Chow) while all others were fed a high FR diet. At 6 wks, FR rats were heavier than RMS and SC-FR, though not SC-Chow (FR=185±13; RMS=173±10;SC =160±12;SC-Chow =183±2). Retro-peritoneal fat pads were heavier in FR vs. SC-FR (2.16±0.24 vs. 1.00±0.22 g, p<0.013), but did not differ among other groups. Oral glucose tolerance was similar in all groups but FR rats were moderately hyperinsulinemic following the glucose challenge (p<0.12). In muscle, GLUT4 content was reduced by ∼30% in FR rats vs. all other groups (p<0.05) although PGC-1 protein mass was unaffected by diet. Fatty acid uptake into membrane vesicles from heart, muscle and adipose did not differ among groups, and SREBP-1c content in adipose tissue was not altered by diet. Continuing exposure to dietary FR promotes increased body weight and adipose accumulation, possibly through changes in insulin but not SREBP-1c and PGC-1. Impairment in glucose tolerance and fatty acid uptake may emerge as rats mature.
- Subjects
FRUCTOSE; BODY weight; FATTY acids; GLUCOSE; ADIPOSE tissues; INSULIN
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA1197
- ISSN
0892-6638
- Publication type
Article