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- Title
Inactivation of p16<sup>INK4a</sup> (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment.
- Authors
Maurelli, Riccardo; Zambruno, Giovanna; Guerra, Liliana; Abbruzzese, Claudia; Dimri, Goberdhan; Gellini, Mara; Bondanza, Sergio; Dellambra, Elena
- Abstract
Investigates the role of inhibitor of cyclin-dependent kinase 4A in human keratinocyte clonal evolution. Percentage of stem and transient amplifying cells in the transduced cultures; Histological and immunohistochemical analysis of in vitro reconstituted skin equivalents; Physiological effect of the down-regulation of Bmi-1.
- Subjects
CYCLIN-dependent kinases; PROTEIN kinases; KERATINOCYTES; STEM cells; IMMUNOHISTOCHEMISTRY; SKIN
- Publication
FASEB Journal, 2006, Vol 20, Issue 9, p1516
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-4480fje