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- Title
Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels.
- Authors
O'Malley, Dervla; Irving, Andrew J.; Harvey, Jenni
- Abstract
Assesses the effects of leptin on the subcellular distribution of phosphatidyl linositol (PtdIns) (3,4,5) P3 and BK channels in hippocampal neurons. Activation of BK channels by leptin; Role of leptin in promoting rearrangement of actin filaments via a PI 3-kinase-driven pathway; Impact of leptin on PtdIns (3,4,5) P3 levels at synapses and on BK channels at synapses.
- Subjects
PHOSPHOINOSITIDES; LEPTIN; NEURONS; HIPPOCAMPUS (Brain); ACTIN; SYNAPSES
- Publication
FASEB Journal, 2005, Vol 19, Issue 13, p1917
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-4166fje