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- Title
GC/MS-Based Metabolomics Approach to Evaluate the Effect of Jackyakgamcho-Tang on Acute Colitis.
- Authors
Seo, Seung-Ho; Park, Seong-Eun; Kim, Eun-Ju; Youn, Daehwan; Lee, Yu-Mi; Lee, Soon-Young; Bok, So-Hyeon; Park, Dae-Hun; Seo, Chang-Seob; Byun, Sung-Hoon; Jun, Ki Young; Kim, Dae Sung; Na, Chang-Su; Son, Hong-Seok
- Abstract
The objective of this study was to examine the effects of Jackyakgamcho-tang (JGT) on acute colitis. GC/MS-based metabolomics and NGS-based metagenomics were applied to investigate the alteration of metabolites and microbiota in an acute colitis model. The severity of acute colitis symptoms was alleviated by JGT treatment. Induction of colitis and JGT treatment changed compositions of gut microbiota and inflammatory cytokine levels (TNF-α and IL-6). They also substantially change metabolites (i.e., lactic acid, linoleic acid, monostearin, and palmitoylglycerol). In addition, some clear correlations were observed among metabolites, cytokine, and microbiota. This study highlights the applicability of metabolomics and metagenomics study for evaluating anti-inflammatory effects of a new functional herbal medicine as a therapeutic agent for acute colitis.
- Subjects
SOUTH Korea; THERAPEUTIC use of plant extracts; ANIMAL experimentation; BIOLOGICAL models; COLITIS; CYTOKINES; GAS chromatography; HERBAL medicine; MASS spectrometry; RATS; PLANT extracts; GENOMICS; GUT microbiome; METABOLOMICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2019, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2019/4572764