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- Title
Efficient synthetic routes to uncommon thiazole-tethered 1,2,4-oxadiazole derivatives.
- Authors
Shaikh, Abdul Latif N.; Mhaske, Pravin C.; Jagadale, Shivaji M.; Abhale, Yogita K.; Nandurkar, Yogesh M.
- Abstract
Thiazole and 1,2,4-oxadiazole are influential scaffolds in drug discovery and development processes mainly due to the appreciable diversity in the biological actions of their derivatives. Herein, for the first time, we describe a mild and efficient method for the synthesis of thiazole-tethered 1,2,4-oxadiazole derivatives. A small focused library of uncommon 3-aryl-5-[(2-arylthiazol-4-yl)methyl]-1,2,4-oxadiazole derivatives have been efficiently synthesized by employing modified reaction conditions using DMAP and EDC·HCl. The title compounds were characterized by IR, NMR and mass spectroscopic analysis.
- Subjects
DRUG discovery; BIODIVERSITY; DRUG development
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2023, Vol 2023, p1
- ISSN
1551-7004
- Publication type
Article
- DOI
10.24820/ark.5550190.p011.912