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- Title
Maggot Antimicrobial Peptide Effect on TGF-β<sub>4</sub> and TNF-α mRNA Expression in Small Intestinal Mucosa from Salmonella pullorum-Infected Chickens.
- Authors
Wang, Z. T.; Wang, J. G.; Zhang, Y. S.; Zhang, X. L.; Xi, J. F.; Li, C. C.; Huang, C. F.; Shen, H.
- Abstract
To explore the effects of maggot antimicrobial peptide treatment of Salmonella pullorum-infected chickens on the mRNA expression levels of TGF-β4 and TNF-α in small intestinal mucosa, the duodenum, jejunum and ileum mucosa were isolated 3, 5 and 7 days after induced AMP, non-induced AMP, antibiotics or maggot treatment and the TGF-β4 and TNF-α mRNA expression was evaluated by quantitative real-time PCR. We found that mRNA of TGF-β4 was highly expressed in the duodenum, jejunum, and ileum when Salmonella pulloruminfected chickens were treated with antibiotics, non-induced AMP, and AMP, respectively (P<0.001). Similarly, TNF-α mRNA was highly expressed in the duodenum and jejunum when Salmonella pullorum-infected chickens were treated with induced AMP and maggots, respectively (P<0.001), and the expression of TNF-α mRNA was higher in response to the use of induced AMP than antibiotics on day 5 after treatment (P<0.05). Therefore, maggot AMP functional efficiency, along with evaluation of TGF-β4 and TNF-α produced by small intestinal mucosa, may be useful for the prevention and treatment of Salmonella pullorum when developing new chicken feed additives.
- Subjects
MESSENGER RNA; ANTIBIOTICS; SALMONELLA; ANTIMICROBIAL peptides; INTESTINAL mucosa
- Publication
Pakistan Veterinary Journal, 2017, Vol 37, Issue 3, p281
- ISSN
0253-8318
- Publication type
Article