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- Title
Current knowledge of protein palmitoylation in gliomas.
- Authors
Tang, Feng; Liu, Zhenyuan; Chen, Xi; Yang, Jinzhou; Wang, Zefen; Li, Zhiqiang
- Abstract
Malignant tumor cells can obtain proliferative benefits from deviant metabolic networks. Emerging evidence suggests that lipid metabolism are dramatically altered in gliomas and excessive fatty acd accumulation is detrimentally correlated with the prognosis of glioma patients. Glioma cells possess remarkably high levels of free fatty acids, which, in turn, enhance post-translational modifications (e.g. palmitoylation). Our and other groups found that palmitoylational modification is essential for remaining intracellular homeostasis and cell survival. Disrupting the balance between palmitoylation and depalmitoylation affects glioma cell viability, apoptosis, invasion, self-renew and pyroptosis. In this review, we focused on summarizing roles and relevant mechanisms of protein palmitoylational modification in gliomas.
- Subjects
PALMITOYLATION; GLIOMAS; FREE fatty acids; POST-translational modification; LIPID metabolism
- Publication
Molecular Biology Reports, 2022, Vol 49, Issue 11, p10949
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-022-07809-z