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- Title
Age‐related differences in macromolecular resonances observed in ultra‐short‐TE STEAM MR spectra at 7T.
- Authors
Genovese, Guglielmo; Terpstra, Melissa; Filip, Pavel; Mangia, Silvia; McCarten, J. Riley; Hemmy, Laura S.; Marjańska, Małgorzata
- Abstract
Purpose: To understand how macromolecular content varies in the human brain with age in a large cohort of healthy subjects. Methods: In‐vivo 1H‐MR spectra were acquired using ultra‐short TE STEAM at 7T in the posterior cingulate cortex. Macromolecular content was studied in 147 datasets from a cohort ranging in age from 19 to 89 y. Three fitting approaches were used to evaluate the macromolecular content: (1) a macromolecular resonances model developed for this study; (2) LCModel‐simulated macromolecules; and (3) a combination of measured and LCModel‐simulated macromolecules. The effect of age on the macromolecular content was investigated by considering age both as a continuous variable (i.e., linear regressions) and as a categorical variable (i.e., multiple comparisons among sub‐groups obtained by stratifying data according to age by decade). Results: While weak age‐related effects were observed for macromolecular peaks at ˜0.9 (MM09), ˜1.2 (MM12), and ˜1.4 (MM14) ppm, moderate to strong effects were observed for peaks at ˜1.7 (MM17), and ˜2.0 (MM20) ppm. Significantly higher MM17 and MM20 content started from 30 to 40 y of age, while for MM09, MM12, and MM14, significantly higher content started from 60 to 70 y of age. Conclusions: Our findings provide insights into age‐related differences in macromolecular contents and strengthen the necessity of using age‐matched measured macromolecules during quantification.
- Subjects
CINGULATE cortex; RESONANCE; MULTIPLE comparisons (Statistics); MACROMOLECULES
- Publication
Magnetic Resonance in Medicine, 2024, Vol 92, Issue 1, p4
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.30061