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- Title
Whole‐brain steady‐state CEST at 3 T using MR Multitasking.
- Authors
Han, Pei; Cheema, Karandeep; Lee, Hsu‐Lei; Zhou, Zhengwei; Cao, Tianle; Ma, Sen; Wang, Nan; Han, Hui; Christodoulou, Anthony G.; Li, Debiao
- Abstract
Purpose: To perform fast 3D steady‐state CEST (ss‐CEST) imaging using MR Multitasking. Methods: A continuous acquisition sequence with repetitive ss‐CEST modules was developed. Each ss‐CEST module contains a single‐lobe Gaussian saturation pulse, followed by a spoiler gradient and eight FLASH readouts (one "training line" + seven "imaging lines"). Three‐dimensional Cartesian encoding was used for k‐space acquisition. Reconstructed CEST images were quantified with four‐pool Lorentzian fitting. Results: Steady‐state CEST with whole‐brain coverage was performed in 5.6 s per saturation frequency offset at the spatial resolution of 1.7 × 1.7 × 3.0 mm3. The total scan time was 5.5 min for 55 different frequency offsets. Quantitative CEST maps from multipool fitting showed consistent image quality across the volume. Conclusion: Three‐dimensional ss‐CEST with whole‐brain coverage can be done at 3 T within 5.5 min using MR Multitasking.
- Subjects
MAGNETIC resonance imaging; SPATIAL resolution; MAGNETIZATION transfer
- Publication
Magnetic Resonance in Medicine, 2022, Vol 87, Issue 5, p2363
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.29109