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- Title
Synthesis of Carbonyl-Containing Oxindoles via Ni-Catalyzed Reductive Aryl-Acylation and Aryl-Esterification of Alkenes.
- Authors
Ding, Zhengtian; Kong, Wangqing
- Abstract
Carbonyl-containing oxindoles are ubiquitous core structures present in many biologically active natural products and pharmaceutical molecules. Nickel-catalyzed reductive aryl-acylation of alkenes using aryl anhydrides or alkanoyl chlorides as acyl sources is developed, providing 3,3-disubstituted oxindoles bearing ketone functionality at the 3-position. Moreover, nickel-catalyzed reductive aryl-esterification of alkenes using chloroformate as ester sources is further developed, affording 3,3-disubstituted oxindoles bearing ester functionality at the 3-position. This strategy has the advantages of good yields and high functional group compatibility.
- Subjects
OXINDOLES; ALKENES; KETONES; AMINATION; ACYL chlorides; ANHYDRIDES; NATURAL products
- Publication
Molecules, 2022, Vol 27, Issue 18, p5899
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27185899