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- Title
The effect of a single intramammary infusion of a biological response modifier in cows at drying off.
- Authors
Dallard, Bibiana; Ortega, H.; Iguzquiza, I.; Salvetti, N.; Quaino, O.; Calvinho, L.
- Abstract
Biological response modifiers (BRM) are compounds that interact with the immune system to regulate specific aspects of host response. The objective of this study was to describe clinical and morphological changes during involution of bovine mammary gland following a single-dose infusion of a BRM containing lipopolysaccharide and cellular fractions of Escherichia coli incorporated into liposomes. A massive leukocyte response and increased subepithelial stroma infiltration of mononuclear cells, eosinophils and mast cells was observed in BRM-treated quarters compared with untreated controls; however, morphologic parameters assessed at 11 days post infusion were indicative of only slightly accelerated involution compared with untreated controls. In addition, BRM infusion at the end of lactation did not interfere with mammary epithelial cell proliferation and caused only mild systemic effects.
- Subjects
TREATMENT of mastitis; IMMUNOMODULATORS; IMMUNE system; MAMMARY glands; ESCHERICHIA coli infections in animals; CELL proliferation
- Publication
Veterinary Research Communications, 2010, Vol 34, Issue 6, p519
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-010-9423-0