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- Title
Method for the preparation of 4-aryl-3-pyrrolin-2-ones and their 5-bromo derivatives.
- Authors
Vorona, M.; Orlova, N.; Kuznetsov, E.; Vikainis, S.; Liepinsh, E.; Belyakov, S.; Mishnev, A.; Veinberg, G.
- Abstract
An effective method for the conversion of 1-acetyl-4-phenyl-2-pyrrolidone into 1-acetyl-4-phenyl-3-pyrrolin-2-one by bromination-dehydrobromination with N-bromosuccinimide, catalyzed by azo-bisisobutyronitrile or by UV irradiation is developed. The method was extended to the 1-acetyl-4-phenyl-3-pyrrolin-2-one structural analogs. An employment of an excess of N-bromosuccinimide under given reaction conditions leads to the bromination of 1-acetyl-4-phenyl-3-pyrrolin-2-one and its structural analogs at position 5.
- Subjects
BROMOSUCCINIMIDE; BROMINATION; DEHYDROBROMINATION; IRRADIATION; BUTYRONITRILE; CHEMICAL reactions
- Publication
Chemistry of Heterocyclic Compounds, 2013, Vol 49, Issue 8, p1118
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-013-1352-8