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- Title
Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy.
- Authors
Lin, Daphne P. L.; Carnagarin, Revathy; Dharmarajan, Arun; Dass, Crispin R.
- Abstract
Objectives Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful. Key findings The potent osteoinductive effects of the bone morphogenetic protein-2 are largely implicated in the transdifferentiation of myoblast to osteoblast. Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. The upregulation of the activating protein-1 binding activity triggers the transcription of the runt-related transcription factor 2 gene, a transcription factor that plays a major role in osteoblast differentiation. Summary This potential transdifferentiation treatment may be utilised for dental implants, fracture healing, osteoporosis and bone repair post-destruction by bone tumours.
- Subjects
MYOBLASTS; OSTEOBLASTS; CELL differentiation; SMAD proteins; TREATMENT of bone diseases; GENETIC transcription; BONE morphogenetic proteins; PHYSIOLOGY
- Publication
Journal of Pharmacy & Pharmacology, 2017, Vol 69, Issue 12, p1661
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12790