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- Title
Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer.
- Authors
MENG-FENG WU; YUN-CHI WANG; TE-CHUN SHEN; WEN-SHIN CHANG; HSIN-TING LI; CHENG-HSI LIAO; CHI-LI GONG; ZHI-HONG WANG; CHIA-WEN TSAI; TE-CHUN HSIA; DA-TIAN BAU
- Abstract
Background/Aim: Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility. Materials and Methods: IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16 rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16 rs11556218 heterozygous variant TG and homozygous variant GG were 36.6 and 7.3% among the lung cancer patients, significantly higher than those among the controls (22.5% and 2.6%). On the other way, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. Conclusion: The present study indicates IL-16 rs11556218 G allele is significantly associated with increased Taiwan lung cancer risk.
- Subjects
TAIWAN; INTERLEUKIN-16; LUNG cancer risk factors; CANCER genetics; GENOTYPES; SINGLE nucleotide polymorphisms
- Publication
In Vivo, 2020, Vol 34, Issue 3, p1117
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.11883