We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predictors of Symptomatic Intracranial Hemorrhage after Endovascular Thrombectomy in Acute Ischemic Stroke Patients with Anterior Large Vessel Occlusion—Procedure Time and Reperfusion Quality Determine.
- Authors
Li, Yan; van Landeghem, Natalie; Demircioglu, Aydin; Köhrmann, Martin; Dammann, Philipp; Oppong, Marvin Darkwah; Jabbarli, Ramazan; Theysohn, Jens Matthias; Altenbernd, Jens-Christian; Styczen, Hanna; Forsting, Michael; Wanke, Isabel; Frank, Benedikt; Deuschl, Cornelius
- Abstract
Purpose: We aimed to evaluate predictors of symptomatic intracranial hemorrhage (sICH) in acute ischemic stroke (AIS) patients following thrombectomy due to anterior large vessel occlusion (LVO). Methods: Data on stroke patients from January 2018 to December 2020 in a tertiary care centre were retrospectively analysed. sICH was defined as intracranial hemorrhage associated with a deterioration of at least four points in the National Institutes of Health Stroke Scale (NIHSS) score or hemorrhage leading to death. A smoothed ridge regression model was run to analyse the impact of 15 variables on their association with sICH. Results: Of the 174 patients (median age 77, 41.4% male), sICH was present in 18 patients. Short procedure time from groin puncture to reperfusion (per 10 min OR 1.24; 95% CI 1.071–1.435; p = 0.004) and complete reperfusion (TICI 3) (OR 0.035; 95% CI 0.003–0.378; p = 0.005) were significantly associated with a lower risk of sICH. On the contrary, successful reperfusion (TICI 3 and TICI 2b) was not associated with a lower risk of sICH (OR 0.508; 95% CI 0.131–1.975, p = 0.325). Neither the total time from symptom onset to reperfusion nor the intravenous thrombolysis was a predictor of sICH (per 10 min OR 1.0; 95% CI 0.998–1.001, p = 0.745) (OR 1.305; 95% CI 0.338–5.041, p = 0.697). Conclusion: Our findings addressed the paramount importance of short procedure time and complete reperfusion to minimize sICH risk. The total ischemic time from onset to reperfusion was not a predictor of sICH.
- Subjects
NATIONAL Institutes of Health (U.S.); STROKE patients; INTRACRANIAL hemorrhage; THROMBOLYTIC therapy; ENDOVASCULAR surgery; REPERFUSION; ISCHEMIC stroke
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 24, p7433
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11247433