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- Title
Electroconvulsive Shock Reduces Inositol Trisphosphate Receptor! mRNA in Rat Brain.
- Authors
Hyun Kim; Im Joo Rhyu; Chang-Mee Kim; Young Suk Suh; Joo-Bae Park; Ung Gu Kang; Yong Sik Kim
- Abstract
We studied the expression pattern of the inositol 1,4,5-trisphosphate receptor1 (InsP3R1) mRNA after a single electroconvulsive shuck (ECS) in the rat brain by in situ hybridization. The expression was significantly decreased in the dentate gyrus and the CA1 area of the hippocampal formation 3 to 24 h after ECS. While the downregulation of InsP3R1 by accelerated protein degradation has been reported, our results indicate that the downregulation of InsP3R1 occurs at the mRNA level. This finding, along with our previous report on the InsP3 3-kinase(A), suggests that ECS regulates the phosphoinositide mediated signaling, which might be related to the therapeutic mechanism of ECS.
- Subjects
MESSENGER RNA; PROTEINS; IN situ hybridization; PHOSPHOINOSITIDES; RATS
- Publication
Molecules & Cells (Springer Nature), 2001, Vol 12, Issue 2, p173
- ISSN
1016-8478
- Publication type
Article
- DOI
10.1016/s1016-8478(23)17079-8