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- Title
Depletion of giant ANK2 in monkeys causes drastic brain volume loss.
- Authors
Qin, Dong-Dong; Zhou, Jian-Kui; He, Xie-Chao; Shen, Xiang-Yu; Li, Cong; Chen, Huan-Zhi; Yan, Lan-Zhen; Hu, Zheng-Fei; Li, Xiang; Lv, Long-Bao; Yao, Yong-Gang; Wang, Zheng; Huang, Xing-Xu; Hu, Xin-Tian; Zheng, Ping
- Abstract
In this study, we evaluated the function of giant ANK2 and its relevance to human nonsyndromic ASDs by using CRISPR/Cas9 gene-edited cynomolgus monkeys ( I Macaca fascicularis i ) and rhesus monkeys ( I Macaca mulatta i ) in which giant ANK2 was specifically knocked out whilst ANK2 remained intact. The structural MRI data for each mutant monkey was compared with specie-specific standard brain atlas instead of species-matched WT controls in this study, as these standard brain atlases were constructed by using more WT individuals[9],[10]. Magnetic resonance imaging (MRI) scanning of monkey brains was performed using a United Imaging UMR 790 3T scanner (Shanghai, China) when monkeys were 6-month, 12-month, and 24-month old.
- Subjects
MONKEYS; RHESUS monkeys; AUTISM spectrum disorders; GENOME editing; TEMPORAL lobe; FRONTAL lobe
- Publication
Cell Discovery, 2021, Vol 7, Issue 1, p1
- ISSN
2056-5968
- Publication type
Letter
- DOI
10.1038/s41421-021-00336-4