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- Title
Is the thin layer of methyl aminolevulinate used during photodynamic therapy sufficient?
- Authors
Wiegell, Stine R.; Lerche, Catharina M.; Wulf, Hans Christian
- Abstract
Background If the recommended 1.0 mm layer of methyl aminolevulinate ( MAL) is used during photodynamic therapy ( PDT) of large areas with multiple actinic keratoses ( AK) huge amounts of cream are needed. Objectives To report the amount of MAL used for PDT of AK and basal cell carcinomas ( BCC) in daily routine. The association of protoporphyrin IX (Pp IX) fluorescence and thickness of MAL was investigated in a randomized paired study in healthy volunteers. Methods Amount of cream used per cm2 during conventional and daylight PDT was recorded. In 16 healthy volunteers, 0.1 mm, 0.2 mm, 0.5 mm and 1.0 mm MAL cream were applied for 3 h on tape-stripped areas on each forearm randomized to light-permeable or light-impermeable occlusion. Pp IX fluorescence was measured. Results Less than 0.4 mm MAL was used during PDT of BCC and 0.2 mm for AK. No difference in Pp IX fluorescence was found between the different thicknesses of MAL using light-impermeable occlusion. Conclusion In daily routine <0.4 mm MAL was used during PDT of BCC and 0.1-0.2 mm MAL during PDT of AK. The recommended 1.0 mm MAL did not result in a higher accumulation of Pp IX compared to thinner MAL layers after light-impermeable occlusion for 3 h.
- Subjects
ACTINIC keratosis; SKIN disease treatment; PHOTODYNAMIC therapy; PHOTOTHERAPY; RANDOMIZED controlled trials; THERAPEUTICS
- Publication
Photodermatology, Photoimmunology & Photomedicine, 2016, Vol 32, Issue 2, p88
- ISSN
0905-4383
- Publication type
Article
- DOI
10.1111/phpp.12227