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- Title
Human Coronavirus Spike Protein Based Multi-Epitope Vaccine against COVID-19 and Potential Future Zoonotic Coronaviruses by Using Immunoinformatic Approaches.
- Authors
Baloch, Zulqarnain; Ikram, Aqsa; Shamim, Saba; Obaid, Ayesha; Awan, Faryal Mehwish; Naz, Anam; Rauff, Bisma; Gilani, Khadija; Qureshi, Javed Anver
- Abstract
Zoonotic coronaviruses (CoV) have emerged twice and have caused severe respiratory diseases in humans. Due to the frequent outbreaks of different human coronaviruses (HCoVs), the development of a pan-HCoV vaccine is of great importance. Various conserved epitopes shared by HCoVs are reported to induce cross-reactive T-cell responses. Therefore, this study aimed to design a multi-epitope vaccine, targeting the HCoV spike protein. Genetic analysis revealed that the spike region is highly conserved among SARS-CoV-2, bat SL-CoV, and SARS-CoV. By employing the immunoinformatic approach, we prioritized 20 MHC I and 10 MHCII conserved epitopes to design a multi-epitope vaccine. This vaccine candidate is anticipated to strongly elicit both humoral and cell-mediated immune responses. These results warrant further development of this vaccine into real-world application.
- Subjects
CORONAVIRUS spike protein; CORONAVIRUSES; COVID-19 vaccines; VACCINE development
- Publication
Vaccines, 2022, Vol 10, Issue 7, pN.PAG
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10071150