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- Title
Strange formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its oxime derivative -- Synthesis, stereochemistry, antibacterial and antifungal activity.
- Authors
KANAGARAJAN, V.; SURESHKUMAR, P.; GOPALAKRISHNAN, M.
- Abstract
Objectives and Methods: A collection of novel N-hydroxy-3,3-dimethyl-2,6- diarylpiperidin-4-one oximes 28-32 are synthesized, characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) and two dimensional Noesy spectroscopic data and evaluate for their in vitro antibacterial and antifungal activities. Results and Conclusion: Compound 32, exerted a wide range of antibacterial activities against the entire tested gram-positive and gram-negative bacterial strains except Escherichia coli, besides compound 30, which is more active against Klebsiella pneumoniae, a gram-negative coccus. Compound 29 exerted strong antifungal activities against Aspergillus flavus and Microsporum gypseum. In addition, compound 32 is more potent against Rhizopus.
- Subjects
OXIMES; STEREOCHEMISTRY; ANTIBACTERIAL agents; ANTIFUNGAL agents; GRAM-negative bacterial diseases
- Publication
European Review for Medical & Pharmacological Sciences, 2010, Vol 14, Issue 9, p597
- ISSN
1128-3602
- Publication type
Article