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- Title
Nitrogen Mustard Based 2-Benzylidene-1-tetralone as ICT-Based Fluorescent Probe for Drug Release Monitoring and Cervical Cancer Therapy.
- Authors
Liang, Yuanwei; Li, Chengpeng; Qiu, Wenhua; Li, Puwang; Yang, Ziming; Lin, Haisheng; Zhao, Yuntao
- Abstract
A series of novel intramolecular charge transfer (ICT) based 2-benzylidene-1-tetralones that contain nitrogen mustard for drug release monitoring and cervical cancer therapy were developed. Their emission wavelength and Stokes shift were up to 550 nm and 142 nm, respectively. These compounds exerted excellent anticancer activity against cervical cancer cells, among which 2-{4-[bis(2-chloroethyl)amino]benzylidene}-7-fluoro-3,4-dihydronaphthalen-1(2H)-one exerted the strongest anti-proliferation activity that inhibited HeLa cell cycle in G2/M phase and induced cell apoptosis, as well as activating pro-apoptotic proteins. Furthermore, the release of 2-{4-[bis(2-chloroethyl)amino]benzylidene}-7-fluoro-3,4-dihydronaphthalen-1(2H)-one probe was monitored to locate in lysosomes and nuclei.
- Subjects
HELA cells; NITROGEN mustards; DRUG monitoring; FLUORESCENT probes; CERVICAL cancer; CANCER treatment
- Publication
Russian Journal of General Chemistry, 2022, Vol 92, Issue 11, p2544
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363222110433