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- Title
Novel Cyanoarylporphyrazines with Triazole Groups at the Macrocycle Periphery as Potential Sensibilizers of Photodynamic Therapy and Optical Probes of Intracellular Viscosity.
- Authors
Lermontova, S. A.; Grigoryev, I. S.; Peskova, N. N.; Balalaeva, I. V.; Boyarskii, V. P.; Klapshina, L. G.
- Abstract
Novel fluorescent dyes of the cyanoarylporphyrazine series containing peripheral triazole groups have been synthesized. Their photophysical properties and the local viscosity effect on the fluorescence have been studied. The experiments with cell cultures have revealed rapid accumulation of the dyes in the cells cytoplasm. Photo- and dark cytotoxicity of the compounds have been evaluated by means of the MTT test.
- Subjects
PORPHYRAZINES; TRIAZOLES; YTTERBIUM compounds; MACROCYCLIC compounds; PHOTODYNAMIC therapy
- Publication
Russian Journal of General Chemistry, 2018, Vol 88, Issue 11, p2339
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363218110154