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- Title
Endoplasmic reticulum and the microRNA environment in the cardiovascular system1.
- Authors
Groenendyk, Jody; Fan, Xiao; Peng, Zhenling; Kurgan, Lukasz; Michalak, Marek
- Abstract
Stress responses are important to human physiology and pathology, and the inability to adapt to cellular stress leads to cell death. To mitigate cellular stress and re-establish homeostasis, cells, including those in the cardiovascular system, activate stress coping response mechanisms. The endoplasmic reticulum, a component of the cellular reticular network in cardiac cells, mobilizes so-called endoplasmic reticulum stress coping responses, such as the unfolded protein response. MicroRNAs play an important part in the maintenance of cellular and tissue homeostasis, perform a central role in the biology of the cardiac myocyte, and are involved in pathological cardiac function and remodeling. In this paper, we review a link between endoplasmic reticulum homeostasis and microRNA with an emphasis on the impact on stress responses in the cardiovascular system.
- Subjects
ENDOPLASMIC reticulum; MICRORNA; CARDIOVASCULAR system; HOMEOSTASIS; HEART cells
- Publication
Canadian Journal of Physiology & Pharmacology, 2019, Vol 97, Issue 6, p515
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2018-0720