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- Title
Transcerebral net exchange of vasoactive peptides and catecholamines during lipopolysaccharide-induced systemic inflammation in healthy humans.
- Authors
Berg, Ronan M.G.; Taudorf, Sarah; Bailey, Damian M.; Dahl, Rasmus H.; Lundby, Carsten; Møller, Kirsten
- Abstract
The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a 4-hour intravenous LPS infusion (0.3 ng·kg−1) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety-Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP, and catecholamines by the Fick principle in 12 volunteers before and after LPS infusion. The cerebrovascular release of ET-1 was enhanced, whereas the transcerebral net exchange of CGRP and catecholamines was unaffected. Our findings thus point towards locally produced ET-1 within the cerebrovasculature as a contributor to cerebral vasoconstriction after LPS infusion.
- Subjects
CATECHOLAMINES; VASOACTIVE intestinal peptide; LIPOPOLYSACCHARIDES; VASOCONSTRICTION; ENDOTHELINS; CALCITONIN; BLOOD flow
- Publication
Canadian Journal of Physiology & Pharmacology, 2018, Vol 96, Issue 3, p313
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2017-0266