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- Title
Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse.
- Authors
Woo Jin Choi; Seong Keun Kim; Hee Kuk Park; Uy Dong Sohn; Wonyong Kim
- Abstract
Shepherd’s purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd’s purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1β [IL-1β], IL-6, and IL-10), and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti- inflammatory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 μg/ml for VRE and 1,000 μ g/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and antisuperbacterial properties, and thus it can be used as a functional food or pharmaceutical.
- Subjects
ANTIBACTERIAL agents; BACTERICIDES; SULFORAPHANE; CAPSELLA; NATURAL foods
- Publication
Korean Journal of Physiology & Pharmacology, 2014, Vol 18, Issue 1, p33
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2014.18.1.33