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- Title
Amoxapine-associated acute respiratory distress.
- Authors
ANDO, Masaru; MIYAZAKI, Eishi; TAKENAKA, Ryu-ichi; OKUBO, Toshiyuki; MATSUNO, Osamu; NUREKI, Shin-ichi; ITO, Kazunobu; TSUDA, Tomiyasu; KUMAMOTO, Toshihide
- Abstract
A 37-year-old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrates on chest CT, including patchy areas of ground-glass opacity, thickening of the interlobular septae and bronchial walls and pleural effusions. BAL showed a predominance of neutrophils, lymphocytes and erythrocytes but not eosinophils. Amoxapine was stopped, resulting in complete resolution of the pulmonary infiltrates. When the patient was re-exposed to amoxapine (52.5 mg total dose), high fever, reduced SaO2 and pulmonary infiltrates reappeared. We concluded that acute respiratory distress may be associated with amoxapine treatment.
- Subjects
HEMOPNEUMOTHORAX; LEUCOCYTES; PLEURAL effusions; PLEURA diseases; RESPIRATORY therapy; RESPIRATORY diseases; THERAPEUTICS
- Publication
Respirology, 2008, Vol 13, Issue 1, p149
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/j.1440-1843.2007.01215.x